Whyte et al 1988

A therapeutic trial using parenteral dichloro-methylene-diphosphonate produced an initial rapid biochemical response, which was not sustained. In fact, stress is a transient phenomenon and SGs are transient structures rapidly disassembling upon removal of the stress condition.

There were also dental abnormalities with bizarre and extensive resorption of the cervical region of the teeth and the root apex.

Another approach to stimulate the chaperone machinery is to develop drugs able to upregulate the expression levels of heat shock proteins HSPs.

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This process is experimental and the keywords may be updated as the learning algorithm improves. Phase separation is extremely sensitive to changes in chemical conditions, thus playing an important role in stress adaptation.

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There is an increased risk of fracture. Indeed, they display a spherical morphology due to surface tension.

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Whyte et al. The enzyme appears to function as an ectoenzyme to regulate extracellular but not intracellular levels of PLP substrate. FET proteins share a common domain architecture Paronetto, Bixler et al. These proteins interact with other proteins through specific domains, thus promoting SG formation Protter and Parker, P granules have been defined as a liquid-like compartment. Expression is so mild in many of the persons presumed to have the dominant disorder that the mating of 2 such individuals might present as the phenotype of infantile hypophosphatasia in an offspring. Johnson-Pais et al. The findings indicated that tissue-nonspecific alkaline phosphatase acts in vitamin B6 metabolism. A destructive focal lesion was found in only 1 other family member, and this legion was mainly expansive, but not clearly osteolytic. Finally, aberrant SGs can undergo disassembly by chaperones, potentiated chaperones, or kinases, and, if not repaired, they undergo degradation by autophagy.

Lia-Baldini et al. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The patients had bone pain and deformities of the long bones associated with osteoporosis. This different localization reflects distinct roles displayed by the two RBPs in paraspeckles formation. These systems display a crucial role in the control of protein aggregation.

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Then, this process continues in the dense fibrillar components sub-region, where also processing and modification of pre-rRNA transcripts occur.

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Adenovirus E1A: Transcription Regulation and Alteration of Cell Growth Control