Recombinant erythropoietin was successfully expressed in P.
Dependent on the underlying disease and endogenous EPO levels, EPO treatment has also been shown to be effective in correcting anemia and reducing the need for blood transfusions in cancer and other diseases.
EPO production increases in response to tissue hypoxia, low arterial oxygen concentration and increased oxygen affinity of RBCs. One of these assays, the exhypoxic polycythemic mouse assay,31 is still used as the reference standard for testing and calibrating EPO preparations and EPO assays.
The total glycoprotein weighs 30 kDa with the peptide backbone weighing 18 kDa.
However, indirect dependence of red cell longevity in the blood on plasma erythropoietin levels has been reported, a process termed neocytolysis.
The extracellular sinding site 1 and Binding site 2 are composed of .
Efficiency of signalling through cytokine receptors depends critically on receptor orientation.